Empress: Proteomics Co-Op

Job description

About Empress Empress is pioneering mechanistic intelligence for drug discovery — helping R&D teams understand what their molecules are doing, what is driving activity, what liabilities may emerge, and which candidates are best positioned to advance. By integrating multi-omics, chemoproteomics, proteomics, transcriptomics, computational inference, knowledge graphs, and CRISPR-based functional validation, Empress turns biological complexity into clearer development decisions. Our platform gives discovery teams access to capabilities that would otherwise require years, specialized infrastructure, and rare cross-functional expertise to build internally. Empress is a privately held biotech conceived by Flagship Pioneering, which brings the courage, long-term vision, and resources needed to realize unreasonable results. The Role We're looking for a Co-op to join our Proteomics team and contribute to the development of Empress's Integromyx and Perturb-seq platforms. You'll get hands-on experience across the full mass spectrometry-based proteomics workflows, from cell culture and sample preparation through LC-MS/MS acquisition on Orbitrap systems, including exposure to chemoproteomics experiments that sit at the intersection of chemistry and biology. You'll work as part of a cross-functional team where your contributions matter from day one. We're looking for someone who is curious, detail-oriented, and eager to develop their skills alongside a team building something new. Key Responsibilities • Set up, maintain, and operate Orbitrap mass spectrometry and associated liquid chromatography systems • Maintain mammalian cell cultures; prepare growth media and expand cells for experiment setup • Execute proteomics sample preparation workflows including protein extraction, fractionation, and LC-MS analysis • Use laboratory automation for sample preparation and processing • Contribute to proteomics and chemoproteomics experiments and support data analysis • Present findings in team and cross-functional meetings; maintain meticulous electronic lab notebook records Basic Qualifications • Currently enrolled in a B.S. or M.S. program in Chemistry, Chemical Biology, Biochemistry, or a related field • Coursework or hands-on laboratory experience in chemical biology, liquid chromatography, or mass spectrometry Preferred Qualifications • Familiarity with analytical techniques with a focus on mass spectrometry, especially Thermo Fisher instrumentation • Experience with liquid chromatography sample preparation and purification • Familiarity with R, Python, or strong interest in learning informatics tools • Interest in lab automation instrumentation • Prior experience with mammalian cell culture About Flagship Pioneering Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com. Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. The pay range for this role is $25 - $35 per hour. This role is a short-term engagement that is not eligible for health and welfare benefits. Retirement benefits may be available after completing a set number of hours. Compensation and benefits information is based on Empress's good faith estimate as of the date of publication and may be modified in the future. Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact [email protected].